Novel phenoxyalkylamine derivatives. IV. Synthesis, Ca2+-antagonistic activity and quantitative structure-activity analysis of .ALPHA.-isopropyl-.ALPHA.-(3-(3-(3-methoxyphenoxy)propylamino)propyl)-.ALPHA.-phenylacetonitrile derivatives.
نویسندگان
چکیده
منابع مشابه
Activity and Quantitative Structure Activity Analysis of ƒ ¿ - Isopropyl - α - [ 3 - [ 3 - ( 3 - methoxyphenoxy ) propylamino ] propyl ] - α - phenylacetonitrile
prepared, and their Ca2+ -antagonistic activity was evaluated. Among these compounds, the N-Me derivatives with m-OMe, p-F, p-Cl, 3,4-(OM4 and 3,5-(OMe)2 substituents on the A ring were found to show higher Ca2+ -antagonistic activity than verapamil . The effect of substituents on the A ring was examined quantitatively using physicochemical substituent parameters and regression analysis. The an...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1988
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.36.4103